Nucleophilic Substitution Reactions (SN1, SN2) Definition, Types, Examples & Uses

Nucleophilic Substitution Reactions (SN1, SN2)

Subject: Chemistry

Book: General Chemistry

Nucleophilic substitution involves a nucleophile replacing a leaving group. SN2 is a one-step reaction with a backside attack, leading to inversion of configuration. SN1 proceeds via a carbocation intermediate and can lead to racemization. Factors like substrate structure, nucleophile strength, solvent polarity, and leaving group ability affect reaction pathways. These concepts are critical in drug synthesis and polymer chemistry.