Topic Details (Notes format)

Peptide Bond Formation

Subject: Chemistry

Book: General Chemistry

Peptide bonds link amino acids in proteins through a condensation reaction between the carboxyl group of one amino acid and the amino group of another. This amide linkage (–CO–NH–) is planar and exhibits partial double-bond character, restricting rotation. Enzymatic machinery in ribosomes orchestrates peptide bond formation, forming polypeptide chains that fold into functional proteins.

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