Topic Details (Notes format)

pKa and pKb

Subject: Chemistry

Book: General Chemistry

pKa (–log Ka) and pKb (–log Kb) quantify acid and base strengths, respectively. Lower pKa values mean stronger acids; lower pKb values mean stronger bases. For conjugate pairs, pKa + pKb = pKw = 14 at 25 °C. These parameters guide buffer design, pharmaceutical formulations, and biochemical processes (e.g., how amino acid side chains behave at physiological pH).

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